› 2mpz

Solid-state NMR

Atomic model of the Abeta D23N "Iowa" mutant using solid-state NMR, EM and Rosetta modeling

Released:
DOI: 10.2210/pdb2mpz/pdb
PDB entry 2mpz coloured by chain, ensemble of 5 models, front view.
PDB entry 2mpz coloured by chain, ensemble of 5 models, side view.
PDB entry 2mpz coloured by chain, ensemble of 5 models, top view.
Source organism: Homo sapiens
Primary publication:
Modeling an in-register, parallel "iowa" aβ fibril structure using solid-state NMR data from labeled samples with rosetta.
Sgourakis NG, Yau WM, Qiang W
Structure 23 216-227 (2015)
PMID: 25543257

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 27-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138397 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(42) Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a
Length: 26 amino acids
Theoretical weight: 2.65 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 686-711; Coverage: 4%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 1%
Refinement method: Rosetta refinement
Expression system: Not provided

Quick links

Citations

9 review citations

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.
Aleksis et al. (2017)
8 more

21 mentions without citation

Amyloid beta: structure, biology and structure-based therapeutic development.
Chen et al. (2017)
20 more