PDBe 2mfr

Solution NMR

Solution structure of the transmembrane domain of the insulin receptor in micelles

Released:
Source organism: Homo sapiens
Primary publication:
Solution structure of the transmembrane domain of the insulin receptor in detergent micelles.
Biochim. Biophys. Acta 1838 1313-21 (2014)
PMID: 24440425

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor subunit beta Chain: A
Molecule details ›
Chain: A
Length: 57 amino acids
Theoretical weight: 6.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P06213 (Residues: 940-988; Coverage: 4%)
Gene name: INSR

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: simulated annealing
Chemical shifts: BMR19568  
Expression system: Escherichia coli