PDBe 2m0b

Solution NMR

Homodimeric transmembrane domain of the human receptor tyrosine kinase ErbB1 (EGFR, HER1) in micelles

Released:
Source organism: Homo sapiens
Entry authors: Lesovoy DM, Bocharov EV, Pustovalova YE, Bocharova OV, Arseniev AS

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 44 amino acids
Theoretical weight: 4.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P00533 (Residues: 634-677; Coverage: 4%)
Gene names: EGFR, ERBB, ERBB1, HER1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 58%
Refinement method: simulated annealing, TORSION ANGLE DYNAMICS
Chemical shifts: BMR18804  
Expression system: Escherichia coli BL21(DE3)