PDBe 2lp1

Solution NMR

The solution NMR structure of the transmembrane C-terminal domain of the amyloid precursor protein (C99)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C99 Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05067 (Residues: 671-770; Coverage: 13%)
Gene names: A4, AD1, APP
Sequence domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 43%
Refinement method: molecular dynamics, simulated annealing
Chemical shifts: BMR15775  
Expression system: Escherichia coli