PDBe 2lp0

Solution NMR

The solution structure of homeodomain-protein complex

Released:
Source organism: Homo sapiens
Primary publication:
Structural basis for homeodomain recognition by the cell-cycle regulator Geminin.
Proc. Natl. Acad. Sci. U.S.A. 109 8931-6 (2012)
PMID: 22615398

Function and Biology Details

Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Homeobox protein Hox-C9 Chain: A
Molecule details ›
Chain: A
Length: 60 amino acids
Theoretical weight: 7.74 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P31274 (Residues: 192-251; Coverage: 23%)
Gene names: HOX3B, HOXC9
Sequence domains: Homeodomain
Structure domains: Homeodomain-like
Geminin Chain: B
Molecule details ›
Chain: B
Length: 20 amino acids
Theoretical weight: 2.33 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75496 (Residues: 171-190; Coverage: 10%)
Gene name: GMNN

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 76%
Refinement method: torsion angle dynamics, simulated annealing, molecular dynamics
Chemical shifts: BMR17407  
Expression system: Escherichia coli