PDBe 2lmj

Solution NMR

Itk-sh3

Released:
Source organism: Homo sapiens
Entry authors: Kristiansen P, Bie Andersen T, Huszenicza Z, Andreotti AH, Spurkland A

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ITK/TSK Chain: A
Molecule details ›
Chain: A
Length: 66 amino acids
Theoretical weight: 7.66 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q08881 (Residues: 171-231; Coverage: 10%)
Gene names: EMT, ITK, LYK
Sequence domains: SH3 domain
Structure domains: SH3 Domains

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 89%
Refinement method: molecular dynamics
Chemical shifts: BMR18119  
Expression system: Escherichia coli BL21