PDBe 2lb3

Solution NMR

Structure of the WW domain of PIN1 in complex with a human phosphorylated Smad3 derived peptide

Released:

Function and Biology Details

Reaction catalysed:
Peptidylproline (omega=180) = peptidylproline (omega=0)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.23 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13526 (Residues: 6-41; Coverage: 22%)
Gene name: PIN1
Sequence domains: WW domain
Mothers against decapentaplegic homolog 2 Chain: B
Molecule details ›
Chain: B
Length: 8 amino acids
Theoretical weight: 887 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15796 (Residues: 217-224; Coverage: 2%)
Gene names: MADH2, MADR2, SMAD2

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 48%
Refinement method: simulated annealing
Chemical shifts: BMR17545  
Expression systems:
  • Escherichia coli
  • Not provided