PDBe 2lay

Solution NMR

Structure of the first WW domain of human YAP in complex with a phosphorylated human Smad1 derived peptide

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional coactivator YAP1 Chain: A
Molecule details ›
Chain: A
Length: 36 amino acids
Theoretical weight: 4.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P46937 (Residues: 170-205; Coverage: 7%)
Gene names: YAP1, YAP65
Sequence domains: WW domain
Mothers against decapentaplegic homolog 1 Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.06 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q15797 (Residues: 201-209; Coverage: 2%)
Gene names: BSP1, MADH1, MADR1, SMAD1

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 39%
Refinement method: simulated annealing
Chemical shifts: BMR17540  
Expression systems:
  • Escherichia coli
  • Not provided