PDBe 2lax

Solution NMR

Structure of first WW domain of human YAP in complex with a human Smad1 doubly-phosphorilated derived peptide.


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transcriptional coactivator YAP1 Chain: A
Molecule details ›
Chain: A
Length: 40 amino acids
Theoretical weight: 4.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P46937 (Residues: 170-205; Coverage: 7%)
Gene names: YAP1, YAP65
Sequence domains: WW domain
Mothers against decapentaplegic homolog 1 Chain: B
Molecule details ›
Chain: B
Length: 9 amino acids
Theoretical weight: 1.14 KDa
Source organism: Homo sapiens
Expression system: Not provided
  • Canonical: Q15797 (Residues: 201-209; Coverage: 2%)
Gene names: BSP1, MADH1, MADR1, SMAD1

Ligands and Environments

No bound ligands

2 modified residues:

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 45%
Refinement method: simulated annealing
Chemical shifts: BMR17539  
Expression systems:
  • Escherichia coli
  • Not provided