PDBe 2ks1

Solution NMR

Heterodimeric association of Transmembrane domains of ErbB1 and ErbB2 receptors Enabling Kinase Activation

Released:

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Epidermal growth factor receptor Chain: B
Molecule details ›
Chain: B
Length: 44 amino acids
Theoretical weight: 4.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P00533 (Residues: 634-677; Coverage: 4%)
Gene names: EGFR, ERBB, ERBB1, HER1
Structure domains: Immunoglobulin FC, subunit C
Receptor tyrosine-protein kinase erbB-2 Chain: A
Molecule details ›
Chain: A
Length: 44 amino acids
Theoretical weight: 4.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04626 (Residues: 641-684; Coverage: 4%)
Gene names: ERBB2, HER2, MLN19, NEU, NGL
Structure domains: Cytochrome c1, transmembrane anchor, C-terminal

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Escherichia coli