PDBe 2kny

Solution NMR

Fusion construct of CR17 from LRP-1 and ApoE residues 130-149

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the minimal interface between ApoE and LRP.
J. Mol. Biol. 398 306-19 (2010)
PMID: 20303980

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apolipoprotein E; Low-density lipoprotein receptor-related protein 1 515 kDa subunit Chain: A
Molecule details ›
Chain: A
Length: 80 amino acids
Theoretical weight: 8.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07954 (Residues: 2770-2817; Coverage: 1%)
  • Canonical: P02649 (Residues: 147-167; Coverage: 7%)
  • nullnull
Gene names: A2MR, APOE, APR, LRP1
Sequence domains: Low-density lipoprotein receptor domain class A
Structure domains: Low-density Lipoprotein Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 84%
Refinement method: DGSA-distance geometry simulated annealing
Chemical shifts: BMR16483  
Expression system: Escherichia coli