PDBe 2k5b

Solution NMR

Human CDC37-HSP90 docking model based on NMR

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heat shock protein HSP 90-alpha Chain: A
Molecule details ›
Chain: A
Length: 210 amino acids
Theoretical weight: 23.54 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07900 (Residues: 14-223; Coverage: 29%)
Gene names: HSP90A, HSP90AA1, HSPC1, HSPCA
Sequence domains: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Structure domains: Histidine kinase-like ATPase, C-terminal domain
Hsp90 co-chaperone Cdc37, N-terminally processed Chain: B
Molecule details ›
Chain: B
Length: 129 amino acids
Theoretical weight: 15.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q16543 (Residues: 148-276; Coverage: 34%)
Gene names: CDC37, CDC37A
Sequence domains: Cdc37 Hsp90 binding domain
Structure domains: Methane Monooxygenase Hydroxylase; Chain G, domain 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing, torsion angle dynamics
Expression system: Escherichia coli