PDBe 2jqz

Solution NMR

Solution Structure of the C2 domain of human Smurf2

Released:

Function and Biology Details

Reaction catalysed:
(1a) S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [HECT-type E3 ubiquitin transferase]-L-cysteine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + S-ubiquitinyl-[HECT-type E3 ubiquitin transferase]-L-cysteine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
E3 ubiquitin-protein ligase SMURF2 Chain: A
Molecule details ›
Chain: A
Length: 131 amino acids
Theoretical weight: 14.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HAU4 (Residues: 10-140; Coverage: 18%)
Gene name: SMURF2
Sequence domains: C2 domain
Structure domains: C2 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 83%
Refinement method: simulated annealing, torsion angle dynamics
Chemical shifts: BMR15306  
Expression system: Escherichia coli