PDBe 2jle

X-ray diffraction
2.9Å resolution

Novel indazole nnrtis created using molecular template hybridization based on crystallographic overlays

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Reverse transcriptase/RNaseH Chains: A, B
Molecule details ›
Chains: A, B
Length: 566 amino acids
Theoretical weight: 65.22 KDa
Source organism: Human immunodeficiency virus 1
Expression system: Escherichia coli
UniProt:
  • Canonical: NEW Q72547 (Residues: 1-566; Coverage: 100%)
Gene name: pol
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2221
Unit cell:
a: 117.2Å b: 154.6Å c: 155Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.267 0.261 0.351
Expression system: Escherichia coli