PDBe 2jh5

X-ray diffraction
2.5Å resolution

Human Thrombin Hirugen Inhibitor complex

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Hirudin-3A Chain: H
Molecule details ›
Chain: H
Length: 10 amino acids
Theoretical weight: 1.36 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P28507 (Residues: 55-64; Coverage: 15%)
Thrombin heavy chain Chain: D
Molecule details ›
Chain: D
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Thrombin light chain Chain: C
Molecule details ›
Chain: C
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2

Ligands and Environments

3 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2
Unit cell:
a: 70.363Å b: 71.478Å c: 72.106Å
α: 90° β: 100.62° γ: 90°
R-values:
R R work R free
0.188 0.185 0.231
Expression system: Not provided