PDBe 2jeo

X-ray diffraction
2.5Å resolution

Crystal structure of human uridine-cytidine kinase 1

Released:
Source organism: Homo sapiens
Entry authors: Kosinska U, Stenmark P, Arrowsmith C, Berglund H, Busam R, Collins R, Edwards A, Ericsson UB, Flodin S, Flores A, Graslund S, Hammarstrom M, Hallberg BM, Holmberg Schiavone L, Hogbom M, Johansson I, Karlberg T, Kotenyova T, Moche M, Nilsson MEP, Nyman T, Ogg D, Persson C, Sagemark J, Sundstrom M, Uppenberg J, Uppsten M, Thorsell AG, van den Berg S, Weigelt J, Welin M, Nordlund P, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
ATP + uridine = ADP + UMP
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine-cytidine kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 245 amino acids
Theoretical weight: 28.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9HA47 (Residues: 21-243; Coverage: 81%)
Gene names: UCK1, URK1
Sequence domains: Phosphoribulokinase / Uridine kinase family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P6222
Unit cell:
a: 67.971Å b: 67.971Å c: 236.1Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.205 0.204 0.24
Expression system: Escherichia coli