› 2j8h

X-ray diffraction
1.99Å resolution

Structure of the immunoglobulin tandem repeat A168-A169 of titin

Released:
DOI: 10.2210/pdb2j8h/pdb
PDB entry 2j8h coloured by chain, front view.
PDB entry 2j8h coloured by chain, side view.
PDB entry 2j8h coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Rigid conformation of an immunoglobulin domain tandem repeat in the A-band of the elastic muscle protein titin.
Müller S, Lange S, Gautel M, Wilmanns M
J Mol Biol 371 469-80 (2007)
PMID: 17574571

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186812 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Titin Chain: A
Molecule details ›
Chain: A
Length: 197 amino acids
Theoretical weight: 21.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WZ42 (Residues: 31853-32047; Coverage: 1%)
Gene name: TTN
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: I222
Unit cell:
a: 69.584Å b: 87.04Å c: 104.791Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.194 0.193 0.21
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

Muscle giants: molecular scaffolds in sarcomerogenesis.
Kontrogianni-Konstantopoulos et al. (2009)
7 more

3 mentions without citation

A hypertrophic cardiomyopathy-associated MYBPC3 mutation common in populations of South Asian descent causes contractile dysfunction.
Kuster et al. (2015)
2 more