PDBe 2j0f

X-ray diffraction
2.31Å resolution

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Thymidine phosphorylase Chains: A, B, C, D

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAR345
Spacegroup: P21
Unit cell:
a: 103.078Å b: 76.087Å c: 99.575Å
α: 90° β: 98.61° γ: 90°
R-values:
R R work R free
0.248 0.246 0.287
Expression system: Escherichia coli