PDBe 2ipu

X-ray diffraction
1.65Å resolution

PFA1 Fab fragment complexed with Abeta 1-8 peptide

Released:
Source organisms:
Primary publication:
Molecular basis for passive immunotherapy of Alzheimer's disease.
Proc. Natl. Acad. Sci. U.S.A. 104 15659-64 (2007)
PMID: 17895381

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Beta-amyloid protein 40 Chains: P, Q
Molecule details ›
Chains: P, Q
Length: 8 amino acids
Theoretical weight: 978 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 672-679; Coverage: 1%)
Gene names: A4, AD1, APP
If kappa light chain Chains: K, L
Molecule details ›
Chains: K, L
Length: 219 amino acids
Theoretical weight: 24.15 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: A2NHM3 (Residues: 1-219; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
Structure domains: Immunoglobulins
IgG2a Fab fragment Light Chain Kappa Chains: G, H
Molecule details ›
Chains: G, H
Length: 226 amino acids
Theoretical weight: 24.1 KDa
Source organism: Mus musculus
UniProt:
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 43.07Å b: 70.335Å c: 74.197Å
α: 72.32° β: 86.08° γ: 86.02°
R-values:
R R work R free
0.184 0.182 0.225
Expression system: Not provided