PDBe 2ilt

X-ray diffraction
2.3Å resolution

Human 11-beta-Hydroxysteroid Dehydrogenase (HSD1) with NADP and Adamantane Sulfone Inhibitor

Released:

Function and Biology Details

Reaction catalysed:
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo 12-mer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Corticosteroid 11-beta-dehydrogenase isozyme 1 Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 30.42 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P28845 (Residues: 24-285; Coverage: 90%)
Gene names: HSD11, HSD11B1, HSD11L, SDR26C1
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAP 1 x NAP
2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-BM
Spacegroup: I23
Unit cell:
a: 123.871Å b: 123.871Å c: 123.871Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.212 0.209 0.275
Expression system: Not provided