PDBe 2iik

X-ray diffraction
2.55Å resolution

Crystal Structure of human peroxisomal acetyl-CoA acyl transferase 1 (ACAA1)

Released:
Source organism: Homo sapiens
Entry authors: Papagrigoriou E, Johansson C, Smee C, Kavanagh K, Pike ACW, Sundstrom M, Weigelt J, Edwards A, Arrowsmith CH, Gileadi O, Gorrec F, Umeano C, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
Acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
3-ketoacyl-CoA thiolase, peroxisomal Chains: A, B
Molecule details ›
Chains: A, B
Length: 418 amino acids
Theoretical weight: 43.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P09110 (Residues: 30-424; Coverage: 93%)
Gene names: ACAA, ACAA1, PTHIO
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 55.147Å b: 96.845Å c: 142.055Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.181 0.179 0.223
Expression system: Escherichia coli BL21(DE3)