PDBe 2i9b

X-ray diffraction
2.8Å resolution

Crystal structure of ATF-urokinase receptor complex

Released:

Function and Biology Details

Reaction catalysed:
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Urokinase-type plasminogen activator long chain A Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 145 amino acids
Theoretical weight: 16.4 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt:
  • Canonical: NEW P00749 (Residues: 21-163; Coverage: 35%)
Gene name: PLAU
Sequence domains: Kringle domain
Structure domains:
Urokinase plasminogen activator surface receptor Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 279 amino acids
Theoretical weight: 31.11 KDa
Source organism: Homo sapiens
Expression system: Drosophila melanogaster
UniProt: Gene names: MO3, PLAUR, UPAR
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-BM
Spacegroup: P21
Unit cell:
a: 62.914Å b: 281.921Å c: 62.811Å
α: 90° β: 105.41° γ: 90°
R-values:
R R work R free
0.224 0.222 0.265
Expression system: Drosophila melanogaster