PDBe 2hup

X-ray diffraction
2.05Å resolution

Crystal structure of human RAB43 in complex with GDP

Released:
Source organism: Homo sapiens
Entry authors: Wang J, Shen Y, Tempel W, Landry R, Arrowsmith CH, Edwards AM, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-43 Chains: A, B
Molecule details ›
Chains: A, B
Length: 201 amino acids
Theoretical weight: 22.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q86YS6 (Residues: 9-190; Coverage: 86%)
Gene names: RAB41, RAB43
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P3221
Unit cell:
a: 66.447Å b: 66.447Å c: 145.116Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.233 0.286
Expression system: Escherichia coli