PDBe 2hr7

X-ray diffraction
2.32Å resolution

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. 
Biochemical function:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin receptor subunit alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 486 amino acids
Theoretical weight: 55.54 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P06213 (Residues: 28-512; Coverage: 36%)
Gene name: INSR
Sequence domains:
Structure domains:

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-D
Spacegroup: P212121
Unit cell:
a: 103.861Å b: 130.241Å c: 160.924Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.195 0.231
Expression system: Cricetulus griseus