PDBe 2hnt

X-ray diffraction
2.5Å resolution

CRYSTALLOGRAPHIC STRUCTURE OF HUMAN GAMMA-THROMBIN

Released:
Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 36 amino acids
Theoretical weight: 4.1 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 328-363; Coverage: 6%)
Gene name: F2
Thrombin heavy chain Chain: C
Molecule details ›
Chain: C
Length: 70 amino acids
Theoretical weight: 8.01 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 364-433; Coverage: 12%)
Gene name: F2
Structure domains: Trypsin-like serine proteases
Thrombin heavy chain Chain: E
Molecule details ›
Chain: E
Length: 81 amino acids
Theoretical weight: 9.39 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 437-517; Coverage: 14%)
Gene name: F2
Structure domains: Trypsin-like serine proteases
Thrombin heavy chain Chain: F
Molecule details ›
Chain: F
Length: 105 amino acids
Theoretical weight: 11.97 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P00734 (Residues: 518-622; Coverage: 18%)
Gene name: F2
Structure domains: Trypsin-like serine proteases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 126.45Å b: 48.23Å c: 52.43Å
α: 90° β: 96.2° γ: 90°
R-values:
R R work R free
0.156 not available not available
Expression system: Not provided