PDBe 2hko

X-ray diffraction
2.8Å resolution

Crystal structure of LSD1

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc. Natl. Acad. Sci. U.S.A. 103 13956-61 (2006)
PMID: 16956976

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific histone demethylase 1A Chain: A
Molecule details ›
Chain: A
Length: 664 amino acids
Theoretical weight: 73.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O60341 (Residues: 172-835; Coverage: 78%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P6122
Unit cell:
a: 187.113Å b: 187.113Å c: 106.581Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.23 0.23 0.283
Expression system: Escherichia coli BL21(DE3)