PDBe 2h9p

X-ray diffraction
1.91Å resolution

WDR5 in complex with trimethylated H3K4 peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Histone H3.3 Chain: B
Molecule details ›
Chain: B
Length: 11 amino acids
Theoretical weight: 1.29 KDa
Source organism: Xenopus tropicalis
Expression system: Not provided
  • Canonical: Q6P823 (Residues: 2-12; Coverage: 8%)
Gene name: TGas113e22.1
WD repeat-containing protein 5 Chain: A
Molecule details ›
Chain: A
Length: 329 amino acids
Theoretical weight: 36.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase

Ligands and Environments

No bound ligands

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2221
Unit cell:
a: 78.794Å b: 98.727Å c: 80.205Å
α: 90° β: 90° γ: 90°
R R work R free
0.166 0.164 0.203
Expression systems:
  • Not provided
  • Escherichia coli