PDBe 2h9m

X-ray diffraction
1.9Å resolution

WDR5 in complex with unmodified H3K4 peptide


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
WD repeat-containing protein 5 Chains: A, C
Molecule details ›
Chains: A, C
Length: 313 amino acids
Theoretical weight: 34.38 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P61964 (Residues: 24-334; Coverage: 93%)
Gene names: BIG3, WDR5
Sequence domains: WD domain, G-beta repeat
Structure domains: YVTN repeat-like/Quinoprotein amine dehydrogenase
Histone H3.3 Chains: B, D
Molecule details ›
Chains: B, D
Length: 11 amino acids
Theoretical weight: 1.25 KDa
Source organism: Xenopus tropicalis
Expression system: Not provided
  • Canonical: Q6P823 (Residues: 2-12; Coverage: 8%)
Gene name: TGas113e22.1

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P1
Unit cell:
a: 46.951Å b: 61.375Å c: 64.739Å
α: 110.34° β: 91.22° γ: 112.66°
R R work R free
0.207 0.204 0.257
Expression systems:
  • Escherichia coli
  • Not provided