PDBe 2h94

X-ray diffraction
2.9Å resolution

Crystal Structure and Mechanism of human Lysine-Specific Demethylase-1

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure and mechanism of human lysine-specific demethylase-1.
Nat. Struct. Mol. Biol. 13 626-32 (2006)
PMID: 16799558

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific histone demethylase 1A Chain: A
Molecule details ›
Chain: A
Length: 664 amino acids
Theoretical weight: 73.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O60341 (Residues: 172-835; Coverage: 78%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P6122
Unit cell:
a: 187.943Å b: 187.943Å c: 108.741Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.281 0.229 0.281
Expression system: Escherichia coli