PDBe 2h77

X-ray diffraction
2.33Å resolution

Crystal structure of human TR alpha bound T3 in monoclinic space group


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Thyroid hormone receptor alpha Chain: A
Molecule details ›
Chain: A
Length: 269 amino acids
Theoretical weight: 30.98 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P10827 (Residues: 148-370; Coverage: 46%)
Gene names: EAR7, ERBA1, NR1A1, THRA, THRA1, THRA2
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: C2
Unit cell:
a: 117.569Å b: 80.626Å c: 62.614Å
α: 90° β: 121.09° γ: 90°
R R work R free
0.19 0.187 0.238
Expression system: Escherichia coli BL21(DE3)