PDBe 2h08

X-ray diffraction
2.5Å resolution

crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant Y146M

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribose-phosphate pyrophosphokinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 326 amino acids
Theoretical weight: 35.92 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P60891 (Residues: 1-318; Coverage: 100%)
Gene name: PRPS1
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-6A
Spacegroup: R3
Unit cell:
a: 169.914Å b: 169.914Å c: 61.706Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.207 0.207 0.257
Expression system: Escherichia coli BL21(DE3)