PDBe 2h07

X-ray diffraction
2.2Å resolution

crystal structure of human phosphoribosyl pyrophosphate synthetase 1 mutant S132A

Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Entry contents:
1 distinct polypeptide molecule
Ribose-phosphate pyrophosphokinase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 326 amino acids
Theoretical weight: 35.93 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P60891 (Residues: 1-318; Coverage: 100%)
Gene name: PRPS1
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: R3
Unit cell:
a: 170.339Å b: 170.339Å c: 61.72Å
α: 90° β: 90° γ: 120°
R R work R free
0.218 0.218 0.254
Expression system: Escherichia coli BL21(DE3)