PDBe 2fls

X-ray diffraction
2.05Å resolution

Crystal structure of Human Glutaredoxin 2 complexed with glutathione

Released:
Source organism: Homo sapiens
Entry authors: Johansson C, Smee C, Kavanagh KL, Debreczeni J, von Delft F, Gileadi O, Arrowsmith C, Weigelt J, Edwards A, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin-2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NS18 (Residues: 56-164; Coverage: 67%)
Gene names: CGI-133, GLRX2, GRX2
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 60.201Å b: 60.201Å c: 67.958Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.231
Expression system: Escherichia coli BL21(DE3)