› 2fls

X-ray diffraction
2.05Å resolution

Crystal structure of Human Glutaredoxin 2 complexed with glutathione

Released:
DOI: 10.2210/pdb2fls/pdb
PDB entry 2fls coloured by chain, front view.
PDB entry 2fls coloured by chain, side view.
PDB entry 2fls coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Johansson C, Smee C, Kavanagh KL, Debreczeni J, von Delft F, Gileadi O, Arrowsmith C, Weigelt J, Edwards A, Sundstrom M, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192577 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutaredoxin-2, mitochondrial Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NS18 (Residues: 56-164; Coverage: 67%)
Gene names: CGI-133, GLRX2, GRX2
Sequence domains: Glutaredoxin
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand GSH 1 x GSH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P3221
Unit cell:
a: 60.201Å b: 60.201Å c: 67.958Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.192 0.19 0.231
Expression system: Escherichia coli BL21(DE3)

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