PDBe 2fkl

X-ray diffraction
2.5Å resolution

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain (Residues 126- 189 of APP)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chains: A, B
Molecule details ›
Chains: A, B
Length: 66 amino acids
Theoretical weight: 7.59 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 124-189; Coverage: 9%)
Gene names: A4, AD1, APP
Sequence domains: Copper-binding of amyloid precursor, CuBD
Structure domains: Amyloid beta a4 protein copper binding domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P21
Unit cell:
a: 44.694Å b: 34.823Å c: 50.81Å
α: 90° β: 98.53° γ: 90°
R-values:
R R work R free
0.222 0.222 0.263
Expression system: Komagataella pastoris