PDBe 2fk3

X-ray diffraction
2.4Å resolution

Structure of the Alzheimer's Amyloid Precursor Protein (APP) Copper Binding Domain in 'large unit cell' form

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo octamer
homo tetramer
homo hexamer
homo dimer
homo pentamer
homo trimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
N-APP Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 59 amino acids
Theoretical weight: 6.85 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P05067 (Residues: 133-189; Coverage: 8%)
Gene names: A4, AD1, APP
Structure domains: Amyloid beta a4 protein copper binding domain

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-ID-B
Spacegroup: P212121
Unit cell:
a: 59.623Å b: 67.437Å c: 127.656Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.248
Expression system: Komagataella pastoris