PDBe 2fdb

X-ray diffraction
2.28Å resolution

Crystal Structure of Fibroblast growth factor (FGF)8b in complex with FGF Receptor (FGFR) 2c

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fibroblast growth factor 8 Chains: M, N
Molecule details ›
Chains: M, N
Length: 164 amino acids
Theoretical weight: 18.91 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P55075 (Residues: 52-204; Coverage: 73%)
  • Best match: P55075-3 (Residues: 23-186)
Gene names: AIGF, FGF8
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)
Fibroblast growth factor receptor 2 Chains: P, R
Molecule details ›
Chains: P, R
Length: 220 amino acids
Theoretical weight: 24.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21802 (Residues: 149-368; Coverage: 28%)
  • Best match: P21802-14 (Residues: 149-249)
Gene names: BEK, FGFR2, KGFR, KSAM
Sequence domains: Immunoglobulin I-set domain
Structure domains: Immunoglobulins

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: C2
Unit cell:
a: 170.846Å b: 46.908Å c: 109.616Å
α: 90° β: 91.66° γ: 90°
R-values:
R R work R free
0.239 0.239 0.272
Expression system: Escherichia coli