PDBe 2fd6

X-ray diffraction
1.9Å resolution

Structure of Human Urokinase Plasminogen Activator in Complex with Urokinase Receptor and an anti-upar antibody at 1.9 A

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Urokinase-type plasminogen activator long chain A Chain: A
Molecule details ›
Chain: A
Length: 122 amino acids
Theoretical weight: 13.89 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: NEW P00749 (Residues: 31-152; Coverage: 30%)
Gene name: PLAU
Sequence domains: Kringle domain
Structure domains:
ENSMUSG00000076577 protein Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.44 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: NEW Q52L64 (Residues: 21-239; Coverage: 96%)
Gene names: Gm10883, Igkv8-30
Sequence domains:
Structure domains: Immunoglobulins
V165-D-J-C mu protein Chain: H
Molecule details ›
Chain: H
Length: 213 amino acids
Theoretical weight: 22.98 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: NEW Q924Q0 (Residues: 2-142; Coverage: 99%)
Gene name: V165-D-J-C mu
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins
Urokinase plasminogen activator surface receptor Chain: U
Molecule details ›
Chain: U
Length: 276 amino acids
Theoretical weight: 30.67 KDa
Source organism: Homo sapiens
Expression system: Drosophila
UniProt:
  • Canonical: NEW Q03405 (Residues: 23-297; Coverage: 88%)
Gene names: MO3, PLAUR, UPAR
Sequence domains: u-PAR/Ly-6 domain
Structure domains: CD59

Ligands and Environments

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 51.792Å b: 86.805Å c: 124.69Å
α: 90° β: 94.54° γ: 90°
R-values:
R R work R free
0.239 0.239 0.276
Expression system: Drosophila