PDBe 2f6q

X-ray diffraction
1.95Å resolution

The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)

Released:
Source organism: Homo sapiens
Entry authors: Turnbull A, Lukacik P, Shafqat N, Smee C, Berridge G, Guo K, von Delft F, Weigelt J, Sundstrom M, Arrowsmith C, Edwards A, Gileadi O, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed:
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enoyl-CoA delta isomerase 2, mitochondrial Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 280 amino acids
Theoretical weight: 31.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O75521 (Residues: 137-394; Coverage: 66%)
Gene names: DRS1, ECI2, HCA88, PECI
Sequence domains: Enoyl-CoA hydratase/isomerase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 46.931Å b: 123.196Å c: 128.133Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.215 0.213 0.257
Expression system: Escherichia coli