PDBe 2erj

X-ray diffraction
3Å resolution

Crystal structure of the heterotrimeric interleukin-2 receptor in complex with interleukin-2

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
4 distinct polypeptide molecules
Macromolecules (4 distinct):
Interleukin-2 Chains: D, H
Molecule details ›
Chains: D, H
Length: 133 amino acids
Theoretical weight: 15.4 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P60568 (Residues: 21-153; Coverage: 100%)
Gene name: IL2
Structure domains: Growth Hormone; Chain: A;
Interleukin-2 receptor subunit beta Chains: B, F
Molecule details ›
Chains: B, F
Length: 219 amino acids
Theoretical weight: 25.45 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P14784 (Residues: 27-232; Coverage: 39%)
Gene names: IL15RB, IL2RB
Structure domains: Immunoglobulins
Interleukin-2 receptor subunit alpha Chains: A, E
Molecule details ›
Chains: A, E
Length: 225 amino acids
Theoretical weight: 25.4 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P01589 (Residues: 22-233; Coverage: 85%)
Gene name: IL2RA
Sequence domains: Sushi repeat (SCR repeat)
Structure domains: Complement Module, domain 1
Cytokine receptor common subunit gamma Chains: C, G
Molecule details ›
Chains: C, G
Length: 247 amino acids
Theoretical weight: 29.17 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P31785 (Residues: 23-255; Coverage: 67%)
Gene name: IL2RG
Sequence domains: Interleukin-6 receptor alpha chain, binding
Structure domains: Immunoglobulins

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P1
Unit cell:
a: 57.266Å b: 70.545Å c: 129.236Å
α: 83.85° β: 82.45° γ: 89.72°
R-values:
R R work R free
0.223 0.22 0.263
Expression system: Trichoplusia ni