PDBe 2enq

Solution NMR

Solution structure of the C2 domain from human PI3-kinase p110 subunit alpha

Released:
Source organism: Homo sapiens
Entry authors: Endo H, Nagashima T, Yoshida M, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.63 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P42336 (Residues: 331-481; Coverage: 14%)
Gene name: PIK3CA
Structure domains: C2 domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided