PDBe 2eaw

X-ray diffraction
2.88Å resolution

Human UMP Synthase (C-terminal Domain- Orotidine 5'-Monophosphate Decarboxylase)

Released:
Source organism: Homo sapiens
Entry authors: Liu Y, Tang HL, Pai EF

Function and Biology Details

Reactions catalysed:
Orotidine 5'-phosphate = UMP + CO(2)
Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Uridine 5'-monophosphate synthase Chains: A, B
Molecule details ›
Chains: A, B
Length: 291 amino acids
Theoretical weight: 31.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P11172 (Residues: 190-480; Coverage: 61%)
Gene names: OK/SW-cl.21, UMPS
Sequence domains: Orotidine 5'-phosphate decarboxylase / HUMPS family
Structure domains: Aldolase class I

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P21
Unit cell:
a: 67.571Å b: 59.37Å c: 69.863Å
α: 90° β: 114.3° γ: 90°
R-values:
R R work R free
0.262 0.259 0.307
Expression system: Escherichia coli