PDBe 2e0a

X-ray diffraction
1.86Å resolution

Crystal structure of human pyruvate dehydrogenase kinase 4 in complex with AMPPNP

Released:
Source organism: Homo sapiens

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 394 amino acids
Theoretical weight: 44.77 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q16654 (Residues: 20-411; Coverage: 95%)
Gene names: PDHK4, PDK4
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32B2
Spacegroup: P21
Unit cell:
a: 71.121Å b: 68.456Å c: 79.755Å
α: 90° β: 101.05° γ: 90°
R-values:
R R work R free
0.196 0.196 0.231
Expression system: Spodoptera frugiperda