PDBe 2dfd

X-ray diffraction
1.9Å resolution

Crystal Structure of Human Malate Dehydrogenase Type 2

Released:
Source organism: Homo sapiens
Entry authors: Ugochukwu E, Shafqat N, Rojkova A, Sundstrom M, Arrowsmith C, Weigelt J, Edwards A, von Delft F, Oppermann U, Structural Genomics Consortium (SGC)

Function and Biology Details

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Malate dehydrogenase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 342 amino acids
Theoretical weight: 36.24 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P40926 (Residues: 19-338; Coverage: 95%)
Gene name: MDH2
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 4 x NAD

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 59.943Å b: 152.526Å c: 154.827Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.156 0.194
Expression system: Escherichia coli