PDBe 2d4q

X-ray diffraction
2.3Å resolution

Crystal structure of the Sec-PH domain of the human neurofibromatosis type 1 protein


Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Neurofibromin Chains: A, B
Molecule details ›
Chains: A, B
Length: 257 amino acids
Theoretical weight: 29.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P21359 (Residues: 1581-1837; Coverage: 9%)
Gene name: NF1
Sequence domains: Divergent CRAL/TRIO domain
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P41212
Unit cell:
a: 113.5Å b: 113.5Å c: 125.6Å
α: 90° β: 90° γ: 90°
R R work R free
0.33 0.24 0.28
Expression system: Escherichia coli BL21(DE3)