PDBe 2cs2

Solution NMR

Solution structure of the second Zn-finger domain of poly(ADP-ribose) polymerase-1

Released:
Source organism: Homo sapiens
Entry authors: Nagashima T, Hayashi F, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 1 Chain: A
Molecule details ›
Chain: A
Length: 134 amino acids
Theoretical weight: 14.54 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P09874 (Residues: 103-223; Coverage: 12%)
Gene names: ADPRT, PARP1, PPOL
Sequence domains: Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Structure domains: Zinc finger, PARP-type

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: torsion angle dynamics
Expression system: Not provided