PDBe 2cf9

X-ray diffraction
1.79Å resolution

Complex of recombinant human thrombin with an inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Thrombin heavy chain Chain: H
Molecule details ›
Chain: H
Length: 257 amino acids
Theoretical weight: 29.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 364-620; Coverage: 43%)
Gene name: F2
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Hirudin-3A' Chain: I
Molecule details ›
Chain: I
Length: 11 amino acids
Theoretical weight: 1.4 KDa
Source organism: Hirudo medicinalis
Expression system: Not provided
UniProt:
  • Canonical: P28508 (Residues: 56-65; Coverage: 15%)
Thrombin light chain Chain: L
Molecule details ›
Chain: L
Length: 28 amino acids
Theoretical weight: 3.3 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P00734 (Residues: 334-361; Coverage: 5%)
Gene name: F2

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: C2
Unit cell:
a: 71.29Å b: 71.84Å c: 73.06Å
α: 90° β: 100.56° γ: 90°
R-values:
R R work R free
0.162 0.16 0.198
Expression systems:
  • Cricetulus griseus
  • Not provided