PDBe 2ceo

X-ray diffraction
2.8Å resolution

thyroxine-binding globulin complex with thyroxine

Source organism: Homo sapiens
Primary publication:
Structural mechanism for the carriage and release of thyroxine in the blood.
Proc. Natl. Acad. Sci. U.S.A. 103 13321-6 (2006)
PMID: 16938877

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Thyroxine-binding globulin Chains: A, B
Molecule details ›
Chains: A, B
Length: 379 amino acids
Theoretical weight: 42.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P05543 (Residues: 37-415; Coverage: 96%)
Gene names: SERPINA7, TBG
Sequence domains: Serpin (serine protease inhibitor)
Structure domains:

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.2
Spacegroup: P212121
Unit cell:
a: 73.404Å b: 88.022Å c: 124.118Å
α: 90° β: 90° γ: 90°
R R work R free
0.237 0.235 0.283
Expression system: Escherichia coli BL21(DE3)