PDBe 2cbz

X-ray diffraction
1.5Å resolution

Structure of the human Multidrug Resistance Protein 1 Nucleotide Binding Domain 1


Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Multidrug resistance-associated protein 1 Chain: A
Molecule details ›
Chain: A
Length: 237 amino acids
Theoretical weight: 25.9 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P33527 (Residues: 642-871; Coverage: 15%)
Gene names: ABCC1, MRP, MRP1
Sequence domains: ABC transporter
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-3
Spacegroup: P31
Unit cell:
a: 65.56Å b: 65.56Å c: 64.612Å
α: 90° β: 90° γ: 120°
R R work R free
0.161 0.16 0.187
Expression system: Escherichia coli BL21(DE3)