PDBe 2c5d

X-ray diffraction
3.3Å resolution

Structure of a minimal Gas6-Axl complex

Source organism: Homo sapiens

Function and Biology Details

Reaction catalysed:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Growth arrest-specific protein 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 422 amino acids
Theoretical weight: 46.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: Q14393 (Residues: 261-678; Coverage: 65%)
Gene names: AXLLG, GAS6
Sequence domains: Laminin G domain
Structure domains: Jelly Rolls
Tyrosine-protein kinase receptor UFO Chains: C, D
Molecule details ›
Chains: C, D
Length: 195 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P30530 (Residues: 33-227; Coverage: 22%)
Gene names: AXL, UFO
Sequence domains: Immunoglobulin domain
Structure domains: Immunoglobulins

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P61
Unit cell:
a: 292.951Å b: 292.951Å c: 63.951Å
α: 90° β: 90° γ: 120°
R R work R free
0.241 0.241 0.265
Expression systems:
  • Homo sapiens
  • Escherichia coli BL21