PDBe 2bxs

X-ray diffraction
3.15Å resolution

Human Monoamine Oxidase A in complex with Clorgyline, Crystal Form B


Function and Biology Details

Reaction catalysed:
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Amine oxidase [flavin-containing] A Chains: A, B
Molecule details ›
Chains: A, B
Length: 527 amino acids
Theoretical weight: 59.76 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
  • Canonical: P21397 (Residues: 1-527; Coverage: 100%)
Gene name: MAOA
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments

Cofactor: Ligand FAD 2 x FAD
1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: C2
Unit cell:
a: 158.374Å b: 152.076Å c: 82.203Å
α: 90° β: 104.52° γ: 90°
R R work R free
0.271 0.268 0.33
Expression system: Komagataella pastoris